Increase in testosterone levels and decrease in number of apoptosis in penis and prostate cells by buceng treatment Background: Apoptosis is an important biological mechanism in aging process. vitality, and declining of physiological function. Buceng has been traditionally used to delay aging and enhance male vitality, Administration of buceng to enhance Te concentration and decrease apoptosis in penis and prostate cells has not been educidated. This study is to elucidate the effect of buceng on increase Te concentration and declining of apoptosis in penis and prostate cells of male Sprague Dawley rats. Method: Post test only control group design. 60 male of 90 days old Sprague Dawley rats and ± 300 gram body weight, has been assigned multistage randomly into four group. Group A, the castrated rats, treated with 50 mg buceng. Group B, the rats were not castrated, immediately sacrificed as a positive control. Group C. the castrated rats, got 2 mL of water. as a negative control. Group D, the castrated rats, treated with 6.75 mg mesterolon diluted in water. Manoya statistical model was adopted to analyze the diference consentrction of Te and apoptosis among groups. Analysis was performed by SPSS 13 with 95% confident interval. Result: Manova analysis by Wilk Lambda procedure in four groups indicated that Te concentration, apoptosis in penis and prostate cells among groups were significantly different (p= 0.000). Conclusion: This study concludes that the administration of 50 mg buceng ,for 30 consecutive days could enhance Te concentration and decrease apoptosis in penis and prostate cells.

        Kata kunci: apoptosis, vitality