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OVARIUM HISTOPATHOLOGIC AND ENDOMETRIAL THICKNESS AFTER TREATMENT OF KEPEL FRUIT EXTRACT IN AN EXPERIMENTAL MICE MODEL
Israhnanto Isradji,, Iwang Yusuf,, Suparmi, Dina Fatmawati,,
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Abstract
Kepel(Stelechocarpus burahol) fruit used to prevent a pregnancy by princess palace, but there has been no scientific evidence. This study was conducted to determine the effects of kepel fruit extracts on ovarian histology and endometrial thickness.Ten female Balb/Cmice were used in this study and randomly divided into two groups: group 1 as control(n = 5) was treated water and group 2 (n = 5) was treated with kepel fruit extract on dose 65 mg/kg BBBB for 14 days. All animals weresacrificed by decapitation to obtain ovaries for histologicalexamination and uterus for endometrial thickness. Independent Sample T-Test analysiswas used and statistical significance was defined as p < 0.05.Histopathologic evaluation of ovaries showed that ovaries from the control group have the mean number of primary, secondary, and de Graaf’s follicles were 11.40 ± 5.18, 12.60 ± 4.67, 6.60 ± 1.14, respectively. On the group 2, the mean number of primary, secondary, and de Graaf’s follicles were 20.25 ± 9
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